Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy

Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy

BACKGROUND Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in innate immune cells, its function in other signaling pathways is less clear. Here, we study whethe...

Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus

INTRODUCTION A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of systemic lupus erythematosus (SLE). How the overall activity of PTPN22 is regulated and how the expression of PTPN22 differs between healthy individuals and patients with lupus ar...

UCSD MOLECULE PAGES Tyrosine-protein phosphatase non-receptor type 2

TC-PTP is a ubiquitous non-receptor type protein tyrosine phosphatase that shows highest expression in hematopoietic tissues. It regulates many signal transduction pathways in hematopoietic as well as non-hematopoietic cells. TCPTP has two splice variants, an endoplasmic reticulum-localized TC48, and predominantly nuclear TC45. Upon various stress conditions and insulin stimuli, TC45 comes out ...

PTPN 1 ( protein tyrosine phosphatase , non - receptor type 1 )

PTPRA ( protein tyrosine phosphatase , receptor type , A )

Review on PTPRA, with data on DNA/RNA expression, on the protein encoded, and the functional importance of the gene.